What if there was a series that did NOT center on humanity?
I'm thinking of perhaps the Ancient Bajorans during the age of lightships. Imagine it centering around a single lightship with a small crew of 5-10 people as it explores the Bajoran star system.
I think this would be a functional idea, mainly because the Bajorans are a very human-like culture (A bit more religious, slightly different in appearance, but mostly the same.). And the era described is so heavily undescribed in current canon that it could easily survive without stepping on the toes of other series (Cough, cough, Discovery, cough.).
So that was my idea. What else can be suggested? A GoT lookalike with Klingons perhaps?